Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
نویسندگان
چکیده
منابع مشابه
Cancer Metabolism and Drug Resistance
Metabolic alterations, driven by genetic and epigenetic factors, have long been known to be associated with the etiology of cancer. Furthermore, accumulating evidence suggest that cancer metabolism is intimately linked to drug resistance, which is currently one of the most important challenges in cancer treatment. Altered metabolic pathways help cancer cells to proliferate at a rate higher than...
متن کاملReprogrammed lipid metabolism in bladder cancer with cisplatin resistance
Due to its tendency to recur and acquire chemoresistance quickly, bladder cancer (BC) remains to be an elusive and difficult disease. Patients with recurrent and chemoresistant BC have an extremely poor prognosis. One possible approach that may provide insightful and valuable information regarding resistance mechanisms is looking into the lipid metabolism of BC cells. Metabolism of lipids is es...
متن کاملLipid metabolism in cancer
Dysregulated lipid metabolism is an established hallmark of cancer. Lipids play diverse roles inmaintaining cellular structure, formingmembrane microdomains for functional scaffolding of protein complexes, serving as fat storage depots, and acting as signaling molecules. All of these processes are critical in cancer not only for generating the membrane constituents necessary for proliferating c...
متن کاملBordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic
Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic 1 Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation 2 3 4 5 Nita R. Shah, Robert E. W. Hancock, Rachel C. Fernandez# 6 7 Department of Microbiology and Immunology, The University of British Columbia, Vancouver, 8 Canada, V6T 1Z3 9 10 Running Title: Modified B. pertussis Lipid A Conf...
متن کاملClusterin confers gmcitabine resistance in pancreatic cancer
OBJECTIVE To measure clusterin expression in pancreatic cancer tissues and cell lines and to evaluate whether clusterin confers resistance to gmcitabine in pancreatic cancer cells. METHODS Immunohistochemistry for clusterin was performed on 50 primary pancreatic cancer tissues and 25 matched backgrounds, and clusterin expression in 5 pancreatic cancer cell lines was quantified by Western blot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2018
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2018.05.005